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Publications

1990

Publication

[Lobular carcinoma in situ of the breast].

Chapron C, Laurent JC, Vilain MO, Giard S
• 03/1990

The diagnosis of the lobular carcinoma in situ (LCIS), whose frequency is estimated to range from 0.8 to 3.8 p. cent of breast cancers on the whole, is exclusively anatomopathological since it does not have any specific clinical and/or radiological characteristics. After describing the two main differential diagnoses, the various possible treatments are studied, bearing in mind that the therapeutic strategy must take into account the three characteristics which are typical of LCIS: multicentricity, bilaterality and the possible occurrence of an invasive cancer.

1988

1987

1980

Publication

[Bone dedifferentiation ion during healing of amputated digits of mice, and study of its control].

• 09/1980

481. C R Seances Acad Sci D. 1980 Sep 29;291(4):429-31. [Bone dedifferentiation ion during healing of amputated digits of mice, and study of its control]. Al Samarrae N, Chapron C. Processus of bone dedifferentiation have been shown in Mouse after amputation of the end of digits. Their meaning and their control have been searched for. Chemical sclerosis experiments on blood-vessels and ligature of the superficial femoral artery allowed to show they depended on the blood flow in the limb.

1976

Publication

Relationship of sulfamethazine disposition kinetics to acetylator phenotype in man. A preliminary study.

• 07/1976

485. J Clin Pharmacol. 1976 Jul;16(7):338-44. doi: 10.1002/j.1552-4604.1976.tb01530.x. Relationship of sulfamethazine disposition kinetics to acetylator phenotype in man. A preliminary study. Chapron CJ, Blum MR. The relationship between sulfamethazine disposition kinetics and acetylation phenotype was studied in man. Sulfamethazine pharmacokinetic parameters were determined after the administration of the drug as an oral suspension. When the half-life, acetylation rate constant, or per cent available dose excreted in the urine as acetylsulfamethazine of each subject was plotted on frequency distribution histograms, bimodal distribution patterns were observed. However, when acetylation clearance values were plotted in the same manner, an apparent trimodal pattern was seen. The failure to identify the presumed homozygous rapid acetylator using the commonly employed indices of drug metabolism, i.e., half-life, metabolic rate constant, or per cent of the dose metabolized, was attributed to a significant increase in the apparent volume of distribution of this genotype, as well as the low renal clearance of sulfamethazine found in all genotypes. This preliminary study points out the value of using metabolic clearance as an index of drug metabolizing capacity and suggests its application to further pharmacogenetic studies.

1974

1971

1970